In 1895, Count Dracula commissioned and built a huge hotel, which serves as a safe place for all the monsters of the world. Famous monsters like Frank and his wife Eunice, Wayne and the wolf Wanda, Griffin the invisible man and Murray the mummy, often come to hotels in Transylvania. Today, in Mavis' 118th birthday, Dracula allows his daughter to leave the castle to explore the human world. But Dracula masks zombies as human beings, to scare his daughter and bring her back. The plan works, but the zombies inadvertently lead a 21-year-old human Jonathan Loughran to the monster hotel ...